A large randomised placebo controlled trial among trauma patients with, or at risk of, significant haemorrhage, of the effects of antifibrinolytic treatment on death and transfusion requirement
ISRCTN86750102

 

THE USE OF TRANEXAMIC ACID

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AN HOUR TO SAVE YOUR LIFE; In March 2014 the BBC aired a new programme exploring the life or death decisions facing medical professionals in the first critical hour of emergency care. The programme highlighted the current use of TXA in the UK trauma care, implemented as a direct result of the CRASH-2 collaboraton - something we can all feel proud for!

 

CRASH-2 Prognostic Model: Predicting early death in patients with traumatic bleeding: development and validation of prognostic model

PowerPoint presentation of the trial results

TXA song by BDCC choir

Clips from a BBC drama series Holby City

 

CRASH-2 trial results: Effects of tranexamic acid on death, vascular occlusive
events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial

pdf-version

STOP the Bleeding Campaign

 

ABC Television, Catalyst - Thin blood
Featuring the CRASH-2 trial and our Australian investigators

CRASH-2 subgroup analysis: The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial; CRASH-2 Collaborators

 

Ian Roberts presenting to the Massive Transfusion Consensus Conference in Canada in June 2011

Effect of consent rituals on mortality in emergency care research
Ian Roberts, David Prieto-Merino, Haleema Shakur, Iain Chalmers, Jon Nicholl

Comments from the collaborators

Cost-Effectiveness Analysis of Administering Tranexamic Acid to Bleeding Trauma Patients Using Evidence from the CRASH-2 Trial. Carla Guerriero, John Cairns, Pablo Perel, Haleema Shakur, Ian Roberts

The promise of tranexamic acid, Dr Jerold H Levy, Emory University School of Medicine

Wikipedia

 

Interview of Utako Okamoto, the inventor of tranexamic acid

Cochrane Injuries Group

 

 

 

Implementation of the CRASH-2 results into clinical practice
University of Leicester, Department of Cardiovascular Sciences FAQs

 

 

 

BMC Emergency Medicine
Avoidable mortality from giving tranexamic acid to bleeding trauma patients: an estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial

 

Last updated 7 May 2014