Issue 10 Summer 2007

CRASH2 logo

Every three months Haleema, Maria and I meet to decide what to put in the newsletter. All over the world new hospitals are joining the CRASH-2 trial and many have reached important milestones, but would this make the front page of The Daily Mail, The Kerala Kaumudi or Al Akhbar? Probably not. But we think it should! Thanks to you every week around 100 trauma patients are recruited into the CRASH-2 trial. Many trials published in leading medical journals have less than 100 patients. But CRASH-2 collaborators are recruiting more than this number every week. And every patient recruited makes a permanent contribution to the sum total of medical knowledge.

And collaborators are doing this without being paid (apart from trial related expenses) because they care about trauma patients and want to improve the evidence base for their treatment. THIS IS FRONT PAGE NEWS. All strength to you, and where do we find the phone number of the editor of The Kerala Kaumudi! Ian Roberts

crash2 around the world

Team in National Trauma Centre, Albania, with Fatos Olldashi

NTC team Albania
Aswan team, Egypt
Team in Aswan Teaching Hospital, Egypt, with Mamdouh Alamin
Hospital Universitario "Dr Gustavo Aldereguia Lima“,
Cuba, with Marcos Iraola

GAL team in Cuba

Team at Carlos Manuel de Cespedes Cuba

Hospital General Universitario “Carlos Manuel de Céspedes“, Cuba, with Daimi Ricardo Martinez

St Theresa's Catholic Medical Centre, Cameroon, with Patrick Okwen

Team in Cameroon
Training session in Hospital Universitario del Valle Colombia
Colombia National Co-ordinator Jorge Mejia Mantilla presenting the CRASH2 trial in Hospital Universitario del Valle who have just received their materials and will start randomisation any day now.
Vellore award
Local recognition for CRASH2 collaborator: India’s first ever GurukulJyoti Award for Excellence in Education was awarded to Christian Medical College in Vellore India in February.

which patients for the CRASH2 trial?

The inclusion criteria for the CRASH-2 trial are pragmatic in order to reflect the real life circumstances in which an antifibrinolytic might be used. However, this can be difficult to teach to junior staff in the Emergency Department, as the phrase “any injured patient that you think is bleeding or at risk of bleeding” can be difficult to remember. A useful rule of thumb is to consider the CRASH-2 trial for any trauma patient who has a blood sample taken for a ’group and save’ or ‘cross match’. In an emergency situation staff tend to forget about research, so a good reminder is to place a “Trauma patient? - think about the CRASH-2 trial” sticker onto each blood transfusion form in the resuscitation area, to remind junior staff about the trial. Stickers have been sent to all UK centres and more are available form the Co-ordinating Centre.

The key to successful recruitment to the CRASH-2 trial is to make sure that every potentially eligible patient is considered.

new ethics approvals - and some very quick starters:

ARGENTINA - Julio Horacio Cattaneo, Hospital Angel Cruz Padilla

CAMEROON - Patrick Okwen, St Theresa's Catholic Medical Centre

Laureano Quintero, Hospital Universitario del Valle
Luis Fernando Conde Buitrago, Hospital Universitario Erasmo Meoz

Lensky Aragon Palmero, Hospital Antonio Luande Iraola
Martha Larrea Fabra, Hospital General Calixto Garcia

ECUADOR - Daniel Acosta Farina, Hospital Alcivar

GEORGIA - Nikoloz Kvachadze, Tbilisi State Medical University ER Dept

GHANA - Jonathan Dakubo, Korle Bu Teaching Hospital

Protyush Chatterjee, Bhattacharya Orthopaedic & Related Research Centre
Kabul Chandra Saikia, Gauhati Medical College and Hospital
M Chidambaram, Government Rajaji Hospital
Sasthan Krishna Kumar, Krishna Kumar Orthopaedic Hospital
Sushil Mankar, NKP Salve Institute of Medical Sciences
Pratyush Chaudhuri, Parkar Hospital
Vijay Goni, Postgraduate Institute of Medical Education & Research
Saroj Kumar Jain, Satna Hospital Limited
Subrat Kumar Raul, St Stephen's Hospital

Jorge Martinez Castillo, Hospital General de Ecatepec "Dr José Ma Rodríguez"
Patricia Ortega Leon, Hospital General de Uruapan "Dr Pedro Daniel"
Juan Guerrero Martinez, Hospital General La Perla
Raul Bautista Cruz, Hospital Gustavo Rovirosa Perez

Emmanuel Domingo Inyang, Federal Medical Centre, Yenagoa
Amechi Katchy, National Orthopaedic Hospital Enugu
Stanley Anyanwu, Nnamdi Azikiwe University Teaching Hospital
Pianto Egberipou, Okolobiri General Hospital
John Chukwuemeka Eze, University of Nigeria Teaching Hospital, Enugu
Akpan Otu & Timothy Nottidge, University of Uyo Teaching Hospital

PAKISTAN - Sharad Vyas, Civil Hospital

Cesar Eduardo Malca Polo, Clinica Santa Ana
Pedro Jose Lagos Poma, Hospital IV Essalud Huancayo
Jorge Arturo Flores Del Pozo, Hospital Municipal Los Olivos
Edgar Nunez Huerta, Hospital Nacional Cayetano Heredia

SRI LANKA - Ranjith Ellawala, National Hospital of Sri Lanka,

TANZANIA - Kitugi Samwel Nungu, Muhimbili Orthopaedic Institute,

THAILAND - Sakchai Tangchitvittaya, Suratthani Hospital,

UK - Edward Oforka, Burton Hospitals NHS Trust,

VENEZUELA - Emilio Lozano, Hospital Central Miguel Perez Carreno,

Approaching 6,000 patients

these hospitals have also started randomisation

  • Silvana Svampa, Hospital Castro Rendon, Argentina
  • Gustavo Piñero, Hospital Municipal "Dr Leonidas Lucero", Argentina
  • Adalgiza Reyes Romero, Hospital Universitario del Caribe, Colombia
  • Jorge Augusto Herrera Chaparro, Hospital Universitario San Jose de Popayan, Colombia
  • Irene Pastrana Roman, Hospital Abel Santamaria Cuadrado, Cuba
  • Thorvald Fortun Sampayo, Hospital Miguel Enriquez, Cuba
  • Ashok Pangi, KLE Hospital & Medical Research Centre, India
  • Gordon Rangad, Nazareth Hospital, India
  • Hemant Magar, Sushrut Hospital, India
  • Ignatius Ayo Falope, National Orthopaedic Hospital, Igbobi, Nigeria
  • Nene Obianyo, Enugu State University Teaching Hospital, Nigeria
  • Kalu Ugwu Okam, Federal Medical Centre, Umuahia, Nigeria
  • Zumnan David Songden, University of Abuja Teaching Hospital, Nigeria
  • Andrew Akinbolaji Akinkuolie, Wesley Guild Hospital, Nigeria
  • Marco Gonzáles-Portillo Showing, Hospital Nacional Dos De Mayo, Peru
  • Alonso Soto Tarazona, Hospital Nacional Hipólito Unanue, Peru
  • Mark Nash, University Hospital of North Staffordshire, UK

special achievements - CONGRATULATIONS!


  • Hussein Khamis, Mataria Teaching Hospital, Egypt
  • Carlos Morales, Hospital Universitario San Vicente de Paul, Colombia


  • Bassim Irheim Mohammad, Diwaniyah College of Medicine, Iraq


  • Mamdouh Amin, Aswan Teaching Hospital, Egypt
  • Hesham Elsayed, Suez Canal University, Egypt
  • Surakrant Yutthakasemsunt, Khon Kaen Regional Hospital, Thailand
  • Mario Izurieta, Hospital Luis Vernaza, Ecuador


  • Yashbir Dewan, Christian Medical College Ludhiana, India
  • R R Ravi, Medical Trust Hospital, Kochi, India
  • Sanjay Gupta, Sri Sai Hospital, India
  • Nyoman Golden, Sanglah General Hospital, Indonesia
  • Wu Hoong Chhang, North Bengal Neuro Research Centre, India


  • Tamar Gogichaishvili, Tbilisi State Medical University, Central Clinic, Georgia
  • Gia Tomadze, General Surgery Clinic Tbilisi City Hospital #1, Georgia
  • Juan Diego Ciro, Hospital General de Medellin, Colombia
  • Jorge Mejia Mantilla, Fundación Clínica Valle del Lili, Colombia
  • Wilson Gualteros, Hospital Universitario San Jorge, Colombia