Audio broadcasts

Jaime Miranda, CRASH2 National Co-ordinator, Peru
Sensible guidelines for the conduct of clinical trials
Washington, January 25-26, 2007
Professor Yusuf Salim

Professor Rory Collins
PowerPoint presentation pdf-file

Professor Marc Buyse
PowerPoint presentation pdf-file
Double standards in clinical trial consent
by Sir Iain Chalmers

PowerPoint presentation pdf-file


Dr Salim Yusuf

Professor Salim Yusuf, DPhil, FRCPC, FRSC
Professor of Medicine, McMaster University
Director, Population Health Research Institute
Chief Scientific Officer, McMaster University, Hamilton Health Sciences
Heart and Stroke Foundation Endowed Chair in Cardiovascular Research

Dr. Salim Yusuf is a cardiologist and epidemiologist. After qualifying in medicine from St. John's Medical College, Bangalore, India in 1976, he received a Rhodes Scholarship and obtained a DPhil from Oxford, during which he was involved (along with Richard Peto and Peter Sleight) in initiating the concept of large, simple trials and meta-analysis. He subsequently coordinated the first ISIS trial and served on the steering committee of all subsequent ISIS trials. In 1984, following clinical training in medicine and cardiology in the UK, he moved to the National Institutes of Health, Bethesda, USA. There he applied these principles of large, simple trials to other areas that led to the SOLVD and DIG trials in heart failure. In 1992 he moved to McMaster University and since then has established an international program of research in cardiovascular diseases and prevention.

Dr. Yusuf's recent interests include societal, biologic and genetic determinants of population health in developing populations, and his studies involve over 66 countries in all the inhabited continents of the world.


Professor Rory Collins
University of Oxford
In 1985 Rory Collins became co-director, with Professor Sir Richard Peto, of the University of Oxford's Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU). In 1996 he was appointed Professor of Medicine and Epidemiology at Oxford, supported by the British Heart Foundation. Since September 2005, he has also been acting as the Principal Investigator and Chief Executive of the UK Biobank prospective study of 0.5M British men and women aged 40-69. His work has been in the establishment of large-scale epidemiological studies of the causes, prevention and treatment of heart attacks, other vascular disease, and cancer, while also being closely involved in developing approaches to the combination of results from related studies ("meta-analyses"). CTSU was awarded a Queen's Anniversary Prize for Higher and Further Education in 2006 for its research contributions to public health.


Dr Marc Buyse, ScD, Executive Director and founder of IDDI (International Drug Development Institute), Louvain-la-Neuve, Belgium


Sir Iain Chalmers is a health services researcher, one of the founders of the Cochrane Collaboration, and Editor of the James Lind Library
After qualifying in medicine in the mid 1960s, Iain Chalmers practised as a clinician for seven years in the UK and the Gaza Strip. In the mid 1970s, he became a full time health services researcher with a particular interest in assessing the effects of health care. Between 1978 and 1992, he directed the National Perinatal Epidemiology Unit in Oxford, the coordinating base for the work which led to Effective Care in Pregnancy and Childbirth (ECPC) and The Oxford Database of Perinatal Trials. Because these projects were well received, the National Health Service Research and Development Programme supported efforts to extend the approach to other areas of health care, and Iain Chalmers was appointed in 1992 to direct the UK Cochrane Centre to promote this objective. The following year saw the inauguration of the Cochrane Collaboration ( - an international organisation that aims to help people make well-informed decisions about healthcare by preparing, maintaining and promoting the accessibility of systematic reviews of the effects of healthcare interventions.

At present, Sir Iain Chalmers is the editor of James Lind Library. It has been established to improve general understanding of Fair Tests of treatment which are tests that take steps to obtain reliable information about treatment effects by reducing the misleading influences of biases and the play of chance.